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In comparison, OPCs in CILs and RLs upregulate inflammatory IL-6/JAK/STAT and TNF- pathways, and RL OPCs uniquely activate hypoxia and glycolysis pathways, indicative of metabolic reprogramming and emergence of a stress-adapted state

These diseases show a strong association with HLA-B27, but the strength of this association varies among these various forms and among some of the racial/ethnic groups worldwide

Its bioactivity is primarily attributed to inulina fructan-type polysaccharide (average formula CHO units, -(21) linkages) that constitutes up to 40% of chicory root dry weight (58) and a diverse spectrum of polyphenolic compounds, including chlorogenic acid, chicoric acid, caffeic acid, and flavonoids (5961)

Even though levothyroxine considerably reduces lipid peroxidation, the serum MDA levels never reach the levels seen in healthy individuals (85)